Prevalence of Carbapenem-Resistant Enterobacteriaceae and the Genes Responsible for Carbapenemase Production in a Tertiary Care Hospital in South India

Introduction: Carbapenem resistance in Gram-negative bacilli (GNB) is a major concern the management of resistant infections. The mechanism carbapenem most commonly mediated by carbapenemases. five common genes (NDM, KPC, VIM, OXA, and IMP) are responsible for carbapenemase production. Knowledge these important disease. Objective: To estimate prevalence different production GNB at tertiary healthcare centre South India. Method: In this retrospective study, samples were collected over 16 months. Carbapenem-resistant underwent to Xpert Carba-R assay (Cepheid, Sunnyvale, California, USA) detection production: NDM, IMP. Results: Out 184 carbapenem-resistant GNB, 20 not included study. rest 164 grew Klebsiella pneumoniae (152), Escherichia coli (10), Enterobacter (2). OXA-48 NDM responsible, with 137 (84.5%) 95 (58.6%), respectively. Among them, 70 (43.2%) showed presence both genes, 1 (0.6%) OXA-48, VIM. Individually, 66 (40.7%) 24 (14.8%) one authors did find IMP or KPC genes. Conclusion: As result limited options higher cost antibiotics infections, knowledge helps selection rational use reduces will prevent mortality morbidity from